Preparation and Characterization of Resveratrol-Induced Hydroxyapatite Coating on Magnesium Alloy Surface

ZHU Bowu, LI Douhong, LIU Yali

doi:10.16577/j.issn.1001-1560.2024.0004

Materials Protection >

2024 , Vol. 57 >Issue 1: 21 - 27

DOI: https://doi.org/10.16577/j.issn.1001-1560.2024.0004

Preparation and Characterization of Resveratrol-Induced Hydroxyapatite Coating on Magnesium Alloy Surface

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(1.School of Stomatology，Lanzhou University，Lanzhou 730000，China；2.Ministry of Medicine，Northwest University for Nationalities，Lanzhou 730030，China)

LIU Yali(1991 -)，Master，Research Focus: Biomaterials and Tumor Prevention and Treatment，Tel.:15095318504，E-mail:1432687490＠qq.com

Received date: 2023-03-22

Revised date: 2023-06-14

Accepted date: 2023-07-10

Online published: 2024-01-30

Supported by

The Key Technology Plan Program of Gansu Province(20YF8FA071)；The Stomatology Scientific Research Funds of College of Stomatology Lanzhou University ( Lzukqky-2021-y02)

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Abstract

In order to improve the cell compatibility and corrosion resistance of magnesium alloys，it was expected to prepare a biodegradable medical material in this work.Herein，a composite coating containing resveratrol-hydroxyapatite (BLLC-HA) was prepared on the surface of AZ31 magnesium alloy through a biomimetic mineralization method with the induction effect of resveratrol.Potentiodynamic polarization tests and hydrogen release tests were used to test the corrosion resistance of the coatings.Meanwhile，the MTT method and cell morphology observation method were used to evaluate the human cell compatibility of the samples.The potentiodynamic polarization test results showed that the corrosion potential of AZ31-BLLC-HA (Ecorr ＝-1.152 V) increased by 247 mV compared with the AZ31 group (Ecorr ＝-1.399 V)，and the corrosion current density decreased by three orders of magnitude.The hydrogen release test showed that the average hydrogen release rate in the AZ31 and AZ31-BLLC-HA groups was 1.41 mL/(cm2·d) and 0.41 mL/(cm2·d)，respectively.Moreover，the MTT results showed that the highest cell increment rate was found in AZ31-BLLC-HA，which was significantly higher than that in the negative controls.From the above，it could be obtained that the corrosion resistance of AZ31 magnesium alloy containing hydroxyapatite-resveratrol composite coating was significantly improved，and the degradation rate of this composite material in the simulated body fluid was significantly reduced.Besides，the AZ31 magnesium alloy containing hydroxyapatite-resveratrol composite coating had good cell compatibility.Generally，this composite coating could provide a new idea for functionalization of the surface of medical biomaterials.

Key words： magnesium alloy; resveratrol; hydroxyapatite; biomimetic mineralization; corrosion resistance; cell compatibility

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ZHU Bowu, LI Douhong, LIU Yali . Preparation and Characterization of Resveratrol-Induced Hydroxyapatite Coating on Magnesium Alloy Surface[J]. Materials Protection, 2024 , 57(1) : 21 -27 . DOI: 10.16577/j.issn.1001-1560.2024.0004

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